Lariam (mefloquine hydrochloride) is a prescription-only antimalarial medicine used to prevent infection by Plasmodium falciparum, the most dangerous malaria parasite. It is effective in many regions where other medications may fail due to drug resistance.
Lariam is taken once weekly, making it a convenient option for travellers heading to high-risk areas for extended periods. However, it is essential to evaluate suitability, as Lariam can cause neuropsychiatric side effects in sensitive individuals.
How It Works
Mefloquine, the active ingredient in Lariam, works by disrupting the parasite’s ability to break down and utilise haemoglobin, which is toxic to the malaria parasite. This action kills the parasite before it can multiply and cause illness.
It offers long-acting protection due to its extended half-life, which allows once-weekly dosing.
Why Choose Lariam Tablets
Lariam may be recommended in specific travel scenarios where other malaria treatments are not suitable or available. Its main advantages are:
Once-weekly dosing – ideal for longer trips
Effective in chloroquine-resistant regions
High tissue penetration offering strong prophylaxis
Proven use in military and humanitarian deployments
It is a cost-effective choice but should only be used after a thorough medical history assessment.
Important Note
Start this medication 10 days to 2 weeks before travel to monitor for side effects. Continue weekly during your stay and for 4 weeks after returning. If side effects occur, stop treatment and seek medical advice. Do not use Lariam again in future if adverse effects were experienced previously.
