GPhC Registered Pharmacy — Verified & Trusted
P-Line

E45 Itch Relief Cream – 500g

E45 Itch Relief Cream is a clinically proven, non-greasy emollient that moisturises and relieves itchy, dry skin conditions, including eczema and dermatitis.

£19.99
Order within 0h 0m for next day delivery on all items

1 Test

By starting you agree to our Privacy Policy and confirm you are over 18.

Reviewed by UK-registered prescribers
Discreet next-day delivery
Ongoing clinical support included
GPhC-registered pharmacy

E45 Itch Relief Cream contains an anti-itch ingredient, lauromacrogols, which acts as a topical anaesthetic to soothe the itching caused by eczema, dermatitis, pruritus, and scaling skin conditions. It also contains urea, a moisturiser found naturally within the skin, which helps the skin retain moisture and has a soothing effect. The cream is perfume-free and dermatologically tested, making it suitable for the whole family, including infants over the age of one month.

  • Clinically proven to relieve itching and skin irritation
  • Non-greasy and easily absorbed
  • Perfume-free and dermatologically tested
  • Suitable for all ages, including infants over one month
  • Available in various sizes, including 50g, 100g, and 500g

Directions

How to use:

  • Apply to the affected skin 2 times daily.
  • Ensure the skin is clean and dry before application.

Frequency:

  • Use as needed to relieve itching and maintain skin hydration.

Aftercare:

  • Store below 25°C.
  • Keep out of the sight and reach of children.

Ingredients

Active ingredients per 100g:

  • Urea: 5.0g
  • Lauromacrogols: 3.0g

Other ingredients:

  • Dimeticone
  • Phenyl Dimeticone
  • Liquid Paraffin
  • Cetyl Palmitate
  • Stearic Palmitic Acid
  • Octyldodecanol
  • Glycerol
  • Polysorbate
  • Carbomer
  • Trometamol
  • Benzyl Alcohol
  • Purified Water

Side Effects

Possible Side Effects:

  • Occasionally, allergic reactions or worsening of acne may occur.
  • If you suspect an allergic reaction, such as a rash, or if anything unusual happens, stop using the product.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse.

Please note that fabric (clothing, bedding, dressings, etc.) that has been in contact with this product burns more easily and is a serious fire hazard. Washing clothing and bedding may reduce product build-up but not totally remove it.

How It Works

How it works

No GP appointment needed. Five simple steps to get your treatment delivered.

1

Start Consultation

Begin your online consultation by answering a short medical questionnaire about your health.

2

Choose Treatment

Select your preferred treatment from our range of clinically-approved options.

3

Prescribe

Our UK-registered prescriber reviews your consultation and issues a prescription if appropriate.

4

Review

Our pharmacist clinically checks your prescription and dispenses your medication safely.

5

Delivered to Your Door

Your medication is dispatched in discreet packaging with next-day delivery available.

Patient Reviews

Trusted by thousands

See what our patients are saying about their experience.

Best pharmacy service I've used. Properly supported with check-ins — not just a dispensing machine. Real clinical care.

MS
Mitesh S.Verified Patient

I was nervous about ordering online but the team were so professional and the consultation felt thorough. Highly recommend.

NH
Nicola H.Verified Patient

Incredibly smooth process from start to finish. Medication arrived the next day in discreet packaging. Will definitely use again.

GE
Gareth E.Verified Patient

Patient video stories

Real patients sharing their experience in their own words.

Who Are We

A pharmacy team you can trust

We’re a GPhC-registered pharmacy run by qualified pharmacists and independent prescribers. Every consultation is clinically reviewed — because your health is never just a transaction.

Clinically governed Every order reviewed by a qualified prescriber before dispensing.
Patient-first approach We treat patients, not orders. Clinical support throughout your treatment.
Transparent & compliant Fully compliant with GPhC, MHRA, and NHS standards.
Learn More About Us
Clinical Lead
Dispenser
Pharmacist 1
Pharmacist 2
Prescriber
Support Team

Ready to start your treatment?

Browse our treatments or book a consultation with our pharmacy team today.

Trusted By & Working With