Nitrofurantoin is a widely prescribed antibiotic specifically formulated to target bacterial infections of the urinary tract. It is highly effective against common UTI-causing bacteria such as E. coli and Enterococcus faecalis, and is often a first-choice treatment in uncomplicated UTIs.
Available as 100mg modified-release capsules, Nitrofurantoin is typically taken twice daily for 3 to 7 days, or once daily for long-term prevention of recurrent infections. The modified-release form allows for steady antibiotic levels, reducing the likelihood of missed doses and improving patient compliance.
This antibiotic acts directly in the urinary tract, making it less suitable for infections elsewhere in the body but ideal for bladder infections. It concentrates in the urine, delivering potent antibacterial action at the site of infection. Nitrofurantoin is generally well-tolerated, although some patients may experience gastrointestinal side effects.
How It Works
Nitrofurantoin interferes with bacterial cell metabolism, damaging their DNA and proteins. It is activated in the acidic environment of urine, allowing it to selectively target urinary pathogens without affecting the rest of the body.
Why Choose Nitrofurantoin
Proven first-line treatment for UTIs
High localised effectiveness in the urinary tract
Modified-release form for convenient twice-daily dosing
Suitable for treatment and long-term prevention
Trusted by NHS and widely prescribed across the UK
Important Note
Always complete the full course of treatment even if symptoms resolve early. Take with food to reduce nausea and improve drug levels in the urine.
Nitrofurantoin is not suitable for use in patients with significantly reduced kidney function (eGFR < 45ml/min), and it should not be used in late pregnancy.
