Oestrogel is a transdermal hormone replacement therapy (HRT) that delivers estradiol, a form of oestrogen, through the skin. It is used to manage symptoms of menopause, including hot flushes, night sweats, mood changes, and vaginal dryness, which occur due to falling oestrogen levels.
This gel-based format offers an alternative to oral HRT, providing direct absorption into the bloodstream and avoiding first-pass metabolism by the liver.
How It Works
Oestrogel contains estradiol hemihydrate, which mimics the natural oestrogen produced by the ovaries. After menopause, oestrogen levels decline significantly, leading to various symptoms that can affect quality of life. When applied to the skin, Oestrogel gradually releases estradiol into circulation, helping to restore hormonal balance and reduce menopausal discomfort.
The transdermal application allows for a steady release of hormone, contributing to more stable blood levels and potentially fewer side effects compared to oral HRT.
Why Choose Oestrogel
Oestrogel is a well-established and popular choice for many women undergoing hormone replacement therapy. It offers several advantages:
Non-oral administration avoids gastrointestinal side effects
Flexible dosing based on severity of symptoms
Effective relief from vasomotor symptoms (e.g. hot flushes)
Convenient and discreet once-daily application
Lower risk of blood clots compared to oral HRT in some cases
Its clear, odourless gel dries quickly and is applied to the upper arms or thighs.
Important Note
Oestrogel should be used exactly as prescribed. For women with an intact uterus, a progestogen must be added to the HRT regimen to protect against endometrial cancer. Regular reviews with a healthcare provider are essential, especially for long-term use. Always wash hands after applying and avoid skin contact with others until the gel has dried completely.
Directions
Note: Always follow the instructions in the patient leaflet and from your doctor.
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Dose:
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Application:
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Apply to clean, dry, intact skin of upper arms or thighs
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Rub in gently and allow to dry
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Wash hands immediately after use
Storage:
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Ingredients
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Active Ingredient:
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Key Excipients:
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Ethanol
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Carbomer
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Trolamine
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Purified water
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Side Effects
Common side effects:
Serious (rare):
Report any unusual bleeding, breast changes, or persistent symptoms to a doctor.
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Warnings
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Contraindications:
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Pregnancy/Breastfeeding:
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Drug Interactions:
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Monitoring Required:
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Oestrogel is used to relieve symptoms of the menopause, such as hot flushes, night sweats, mood swings, and vaginal dryness. It delivers oestrogen through the skin as part of hormone replacement therapy (HRT).
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Apply Oestrogel once a day to clean, dry skin on the upper arms, shoulders, or thighs. Let it dry fully before getting dressed, and avoid washing the area for at least an hour.
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Yes, but if you still have your womb, your doctor will usually prescribe a progestogen alongside Oestrogel to protect the womb lining from overgrowth.
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Many women start noticing improvement in their menopause symptoms within a few weeks of using Oestrogel, but it may take up to three months for full effects.
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If you forget to apply Oestrogel, use it as soon as you remember — unless it’s almost time for your next dose. Do not double up to make up for a missed application.
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