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Kliovance

Kliovance is a continuous combined HRT tablet for postmenopausal women.

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Kliovance is a continuous combined hormone replacement therapy (HRT) tablet used to manage symptoms of menopause in women who have not had a period for at least 12 months. It is prescribed to relieve common symptoms such as hot flushes, night sweats, mood swings, and vaginal dryness. Kliovance is also used to prevent osteoporosis in postmenopausal women at high risk of fractures who are unable to take other bone treatments.

How It Works
Kliovance contains two active ingredients: estradiol (a form of oestrogen) and norethisterone acetate (a synthetic progestogen). Estradiol replaces the natural oestrogen that the body no longer produces after menopause, helping to relieve symptoms caused by hormonal decline. Norethisterone counteracts the effects of oestrogen on the endometrial lining, reducing the risk of endometrial hyperplasia or cancer in women with an intact uterus. The combination offers effective symptom relief and uterine protection.

Why Choose Kliovance
Kliovance provides a low-dose, continuous combined HRT option that is well-suited for postmenopausal women looking for simple, once-daily symptom relief. It avoids monthly bleeding by delivering hormones evenly without a break between tablets. Its dual-action formulation makes it effective at relieving a broad range of menopausal symptoms while offering endometrial protection. It is also clinically approved for bone health support in women at risk of osteoporosis.

Important Note
Kliovance should only be used under medical supervision and is not intended for women who are still menstruating or in perimenopause. It is not suitable for use in women with a history of hormone-sensitive cancer, thromboembolic disease, or liver dysfunction. Regular reviews are essential to monitor risks and benefits, especially during long-term treatment. It is not a contraceptive and should not be taken during pregnancy or breastfeeding.

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

  • Take one tablet daily at the same time each day

  • Do not take a break between packs

  • Swallow whole with water, with or without food

  • Do not exceed the prescribed dose

  • Store below 25°C

  • Keep in original packaging

  • Keep out of reach of children

Ingredients

Active Ingredients:

  • Estradiol 1 mg

  • Norethisterone acetate 0.5 mg

Other Ingredients:

  • Lactose monohydrate

  • Maize starch

  • Povidone

  • Magnesium stearate

  • Talc

  • Hypromellose

  • Titanium dioxide

  • Macrogol

Side Effects

Common side effects may include:

  • Breast tenderness

  • Headache

  • Nausea

  • Abdominal pain

  • Irregular bleeding

Serious (rare) side effects:

  • Blood clots

  • Stroke

  • Breast or endometrial cancer

  • Liver dysfunction

  • Depression

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not take Kliovance if allergic to any ingredients. It is contraindicated in women with a history of breast cancer, blood clots, liver disease, or unexplained vaginal bleeding. It is not suitable during pregnancy or breastfeeding. Use caution in those with high blood pressure, diabetes, or migraines. Regular check-ups are essential, and HRT should be reviewed regularly to assess risk.

What is Kliovance used for?

Kliovance is used to relieve common symptoms of the menopause such as hot flushes, night sweats, and vaginal dryness. It also helps protect against bone loss in postmenopausal women.

No, Kliovance is a continuous combined HRT, which means you take it every day without breaks. Most women won’t experience monthly bleeding, although light spotting may occur in the first few months.

Kliovance is suitable for postmenopausal women who haven’t had a period for at least 12 months and still have their womb. It’s not intended for women going through the perimenopause.

If you miss a dose and remember within 12 hours, take it straight away. If more than 12 hours have passed, skip the missed tablet and continue as normal. Don’t take two tablets to make up for the missed one.

Long-term use of Kliovance may be safe for some women but should be reviewed regularly by your doctor. They’ll help weigh the benefits against any potential risks.

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How it works

No GP appointment needed. Five simple steps to get your treatment delivered.

1

Start Consultation

Begin your online consultation by answering a short medical questionnaire about your health.

2

Choose Treatment

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3

Prescribe

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4

Review

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5

Delivered to Your Door

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